Associate Director - Quantitative Systems Pharmacology Modeler
Company: Takeda Pharmaceutical
Location: Peabody
Posted on: May 10, 2022
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Job Description:
By clicking the "Apply" button, I understand that my employment
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with Takeda's Privacy Notice and Terms of Use . I further attest
that all information I submit in my employment application is true
to the best of my knowledge. Job Description Associate Director,
Quantitative Systems Pharmacology Modeler Are you looking for a
patient-focused, innovation-driven company that will inspire you
and empower you to shine? Join us as an Associate Director, Systems
Pharmacology Modeler in our Cambridge, MA office. At Takeda, we are
transforming the pharmaceutical industry through our R&D-driven
market leadership and being a values-led company. To do this, we
empower our people to realize their potential through life-changing
work. Certified as a Global Top Employer, we offer stimulating
careers, encourage innovation, and strive for excellence in
everything we do. We foster an inclusive, collaborative workplace,
in which our global teams are united by an unwavering commitment to
deliver Better Health and a Brighter Future to people around the
world. Here, you will be a vital contributor to our inspiring, bold
mission. POSITION OBJECTIVES: The Quantitative Solutions department
of Takeda Pharmaceuticals is seeking a mechanistic modeler to
support global drug development by building models for novel
therapeutic agents to treat various gastrointestinal diseases
including liver disease and diseases that result from abberant
immune activation within the gut. The successful candidate will
collaborate with preclinical research and drug discovery, DMPK,
clinical pharmacology, clinical research, nonclinical drug safety,
translational medicine and pharmacovigilance to develop
mathematical models to understand the targeted biological pathways
and exposure-response/safety relationship of novel therapeutic
agents. The candidate will also be responsible for implementing the
right modeling & simulation strategy to assist with drug
development, establish PK/PD relationships and create mechanistic
pharmacology/toxicology models to support project needs. Essential
qualifications include in-depth understanding of biochemistry,
immunology, numerical methods, as well as hands-on experience with
modeling software, and ability to clearly present modeling and
simulation findings. POSITION ACCOUNTABILITIES: This is an exciting
opportunity at the interface between clinical pharmacology,
clinical research, nonclinical drug safety, drug discovery, drug
metabolism, translational medicine and pharmacovigilance to
influence drug development. The candidate is expected to design and
build translational PK/PD and mechanistic or platforms models to
assist with safety margin selection, study design and biomarker
selection EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:
Ph.D/Pharm.D/M.D with training in chemical or biomedical
engineering, pharmaceutical sciences, mathematics, statistics, or
equivalent area with at least 7 years of post-graduate industry or
academic experience in mathematical modeling of biological systems.
Job title is flexible based on experience. Strong competency in
coding and running modeling and simulation related software such as
Matlab, NONMEM, Phoenix Winnonlin and R is required. Publication(s)
applying modeling and simulation approaches to gastrointestinal
diseases and immunology is preferred. Proficiency with systems
modeling approaches such as differential equation, logic,
stochastic, agent-based, or other advanced mechanistic modeling
approaches is essential. Demonstrated ability for critical thinking
and strong analytical skills to evaluate complex information to
identify key scientific questions related to projects. Ability to
prioritize and manage multiple projects while meeting project
deadlines. WHAT TAKEDA CAN OFFER YOU: 401(k) with company match and
Annual Retirement Contribution Plan Tuition reimbursement Company
match of charitable contributions Health & Wellness programs
including onsite flu shots and health screenings Generous time off
for vacation and the option to purchase additional vacation days
Community Outreach Programs Empowering Our People to Shine Discover
more at takedajobs.com No Phone Calls or Recruiters Please. In
accordance with the CO Equal Pay Act,--Colorado Applicants Are Not
Permitted to Apply. #LI-KB EEO Statement Takeda is proud in its
commitment to creating a diverse workforce and providing equal
employment opportunities to all employees and applicants for
employment without regard to race, color, religion, sex, sexual
orientation, gender identity, gender expression, parental status,
national origin, age, disability, citizenship status, genetic
information or characteristics, marital status, status as a Vietnam
era veteran, special disabled veteran, or other protected veteran
in accordance with applicable federal, state and local laws, and
any other characteristic protected by law. Locations Boston, MA San
Diego, CA Worker Type Employee Worker Sub-Type Regular Time Type
Full time
Keywords: Takeda Pharmaceutical, Peabody , Associate Director - Quantitative Systems Pharmacology Modeler, Executive , Peabody, Massachusetts
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